The Vu Lab

Publications

Single Cell/Multiplexed Imaging Platforms

Jacob, T, Malla, P, Vu TQ. Miniaturized single cell imaging for developing immuno-oncology combinational therapies. In Methods in Pharmacology and Toxicology Immuno-Oncology: Cellular and Translational Approaches. Pg 157-165. Humana Press. ISSN1557-2153, 2020.

Jacob T, Agarwal A, Ramunno-Johnson D, O'Hare T, Gönen M, Tyner JW, Druker BJ, Vu TQ. Ultrasensitive proteomic quantitation of Cellular signaling by digitized nanoparticle-protein counting. Scientific Reports. 2016 Jun 20;6:28163 (PDF) PMID: 27320899.

Jacob, T., Gray, JW., Troxell, M. & Vu, TQ. Multiplexed imaging reveals heterogeneity of PI3K/MAPK network signaling in breast lesions of known PIK3CA genotype. Breast Cancer Res Treat, 2016. PMID: 27581127

Roberts E, Jacob T, Garsha, K, Ramunno-Johnson D, Ventura, F., Korkola J, Ashworth-Sharpe J, Johnson D, Corless CL, Troxell ML, Barnes M, Gray J, Shanmugam K, Vu TQ. Mapping cancer signaling networks by an integrated multiplexed tissue imaging platform. Technology 04(03):174-193, 2016. (PDF)

Single Molecule Dynamics / Cancer and Nervous System Signaling

Anke Vermehren-Schmaedick, AMark J Olah, Damien Ramunno-Johnson, Keith Lidke, Michael S Cohen, Tania Q Vu. Molecular-Scale Dynamics of Long Range Retrograde BDNF Transport Shaped by Cellular Spatial Context, Frontiers in Neuroscience (Neurotechnology Section), accepted, 2022.

Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell. 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020.

Wai Yan Lam, Yi Wang, Barmak Mostofian, Danielle Jorgens, Sunjong Kwon, KoeiChin, M. Alexandra Carpenter, Thomas Jacob, Katie Heiser, Anurag Agrawal, JingWang, Xiaolin Nan, Young Hwan Chang, Daniel M. Zuckerman, Joe Gray, Marcel Bruchez, Keith A. Lidke, Tania Q. Vu. HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics. bioRxiv, 2019.

Burwitz et al; Hepatocytic expression of human sodiumtaurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques. Nature Communications. 2017 Dec 15;8(1):2146 (PDF) PMID: 29247188

Vermehren-Schmaedick A., Jacob T., Vu TQ. Methodology for detecting and tracking brain-derived neurotrophic factor complexes in neurons using single quantum dots. Neuromethods. 2018-11, 2018.

Vu TQ, Lam WY, Hatch E, Lidke D. Quantum dot for quantitative imaging: from single molecules to tissue. Cell and Tissue Research 360(1):71-86. 2015.

Vermehren-Schmaedick A, Krueger W, Jacob T, Ramunno-Johnson D, Balkowiec A, Lidke KA, Vu TQ. Heterogeneous intracellular trafficking dynamics of brain-derived neurotrophic factor complexes in the neuronal soma revealed by single quantum dot tracking. Plos One 9(4), 2014.

Chiu SK, Manhat BA, DeBenedetti WJ, Brown AL, Fichter KM, Vu TQ, Eastman M, Jiao J, Goforth AM. Aqeous red emitting silicon nanoparticles for cellular imaging: Consequences of protecting against surface passivation by hydroxide and water for stable, red emission Journal of Material Research Vol 28 (02): 216-230), 2013.

Fichter KM., and Vu TQ Tracing the endocytic pathways and trafficking kinetics of cell signaling receptors using single QD nanoparticles. Methods in Molecular Biology: Cellular and Subcellular Nanotechnology. (991:237-47), 2013.

Fichter KM, Flajolet M, Greengard P, Vu TQ. Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots. Proc Natl Acad Sci USA, 107(43):18658-63, 2010.

Sundara Rajan S, Liu HY, and Vu TQ. Ligand-Bound Quantum Dots for Studying the Molecular Scale Dynamics of Receptor Endocytic Trafficking in Live Cells. ACS Nano, 2(6), 1153-1166, 2008. (PDF)

Vu TQ, Sundara Rajan S, and Liu HY. Ligand Bound Quantum Dots for Intracellular Imaging of Neural Receptors. Proceedings of SPIE, Colloidal Quantum Dots for Biomedical Applications, Vol. 6448, 2007.

Sundara Rajan S and Vu, TQ. Quantum Dots Monitor TrkA Receptor Dynamics in the Interior of Neural PC12 Cells. Nano Letters 2006 Sep;6(9):2049-59. (PDF)

Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, and Desai TA. Peptide-Conjugated Quantum Dots Activate Neuronal Receptors and Initiate Downstream Signaling of Neurite Growth, Nano Letters 5(4): 603-607, 2005. (PDF)

Nanoparticle Protein Detection Technology

Beth A. Manhat, Anna L. Brown, Labe A. Black, J. B. Alexander Ross, Katye Fichter, Tania Vu, Erik Richman, and Andrea M. Goforth. One-Step Melt Synthesis of Water-Soluble, Photoluminescent, Surface-Oxidized Silicon Nanoparticles for Cellular Imaging Applications. Chem Mat. 2011. (PDF)

Long BR and Vu TQ. Spatial structure and diffusive dynamics from single particle trajectories using spline analysis. Biophysical Journal, 98(8):1712-21, 2010. (PDF)

Nanotechnology Research: Applications in Nutritional Sciences. Srinivas PR, Philbert M, Vu TQ, Huang, Q, Kokini JL, Saos E, Chen H, Peterson CM, Friedl KE, McDade-Ngutter C, Hubbard V, Starke-Reed P, Miller N, Betz JM, Dwyer J, Milner J, Ross SA. The Journal of Nutrition. 140(1):119-24, 2010. (PDF)

Vu TQ, Rajan SS. Quantum Dot Imaging in for Imaging and Diagnostics. In: At the Building Block Level: Nanotechnology for Biology and Medicine, Editor: Silva, GA. Springer Scientific, 2005.

Nanomaterial Surface Technologies

Zhang F, Ulrich B, Reddy RK, Venkatraman VL, Prasad S, Vu TQ, and Hsu ST. Fabrication of Submicron IrO2 Nanowire Array Biosensor Platform by Conventional Complementary Metal-Oxide-Semiconductor Process. Japanese Journal of Applied Physics, 47(2):1147-1151, 2008.Vartanian KB, Kirkpatrick SJ, McCarty OJ, Vu TQ, Hanson SR, Hinds MT. Distinct Extracellular Matrix Microenvironments of Progenitor and Carotid Endothelial Cells. J Biomed Mater Res A, (epub ahead of print), 2008.

Nehilla, BJ; Vu, TQ; Desai, TA. Stoichiometry-Dependent Formation of Quantum Dot-Antibody Bioconjugates: A Complementary Atomic Force Microscopy and Agarose Gel Electrophoresis Study. J. Phys. Chem. B. 109(44); 20724-20730, 2005. (PDF)

Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, and Desai TA. Ligand-conjugated quantum dots for targeted drug delivery to nerve cells. Proceedings of the Special Topic Conference on Microtechnologies, IEEE in Engineering in Biology and Medicine, Hawaii, pg.152-3, 2005.

Vu TQ, Qian H, Standaert RF, Chowdhurry S, Pepperberg DR. Activation of Neural Receptor Channels Using Neurotransmitter Conjugates Designed for Surface Attachment. Biomaterials, 25(14):1605-2195, 2005. (PDF)

Nehilla BJ, Popat KC, Vu TQ, Chowdhurry S, Standaert RF, Pepperberg DR, and Desai TA. A Neurotransmitter Analog Tethered to a Silicon Platform for Neuro-bioMEMS Applications, Biotechnology and Bioengineering, 87(5):669-674, 2004. (PDF)

Saifuddin U*,Vu TQ*, Rezac M, Qian H, Pepperberg DR, Desai TA. Toward Development of Bioactive, Neurotransmitter-immobilized Surfaces for Interaction with Post-synaptic Membrane Receptors. Journal of Biomedical Materials Research, 66A(1):184-191, 2003. (*co-authors) . (PDF)

Retinal Neuroscience

Vu TQ, Payne JA, Copenhagen DC. Localization and developmental expression patterns of the neuronal K-Cl cotransporter (KCC2) in the rat retina. Journal of Neuroscience 20(4):1414-23, 2000. (PDF)

Krizaj D, Vu TQ, and Copenhagen, DC. On the shaping, modulation, and synaptic transmission of rod and cone light responses. In The Retinal Basis of Vision, Toyoda, J., Murakami, M., Kaneko, A., and Saito, T., Eds. Amsterdam: Elsevier, 1999.

Vu TQ, McCarthy ST, and Owen WG. Linear transduction of natural stimuli by dark-adapted and light-adapted rods of the tiger salamander, Tigris Ambystoma. Journal of Physiology 505 (1): 193-204, 1997. (PDF)